A distribution of two SNPs in exon 10 of the FSHR gene among the women with a diminished ovarian reserve in Ukraine

To evaluate the association between phenotype and follicle stimulating hormone receptor (FSHR) genotype in women with ovarian dysfunction and patients with poor response to gonadotropin stimulation of ovulation. FSHR gene SNPs were analyzed by PCR and RFLP. Poor responders (ovarian dysfunction) group and good responders group constituted the study group. Normo-ovulatory women who gave birth to naturally conceived children formed control groups: under 35 years of age (control I) and over 35 years of age (control II). The frequency of Ala307-Ser680/Ala307-Ser680 genotype was significantly more prevalent in the ovarian dysfunction group (26%) compared to the control I (7.7%) (P < 0.001) and a good responders group (12.5%) (P < 0.05); and in a poor responders group (33.3%) compared to a good responders group (P < 0.05), control I (P < 0.001) and control II (17.5%) (P < 0.05). Our data shows the prevalence of the Ala307-Ser680/ Ala307-Ser680 genotype in the both groups of patients. The finding should have impact on the delineation of stimulation protocols.