期刊
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
卷 25, 期 8, 页码 383-388出版社
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10815-008-9253-y
关键词
Controlled ovarian hyperstimulation; hs-CRP; Inflammation; IVF; Pregnancy rate
资金
- CMMC Trust Research Scheme, UK [9671, 2004/05]
Purpose To assess the relationship between low-grade inflammation, measured as basal high sensitivity (hs)-CRP, and IVF outcome. Methods We recruited a total of 220 women undergoing infertility work up prior to IVF. Patients were selected for a BMI < 30 kg/m(2) with an upper age limit of 40 years. Serum hs-CRP levels were measured on day 3 of a spontaneous menstrual cycle preceding ovarian stimulation. A sensitive two-site ELISA was used for analysis. Dose of gonadotrophins required, follicles days 8 and 10, number of oocytes collected, number of oocytes fertilised and pregnancy outcome were recorded. Results Median hs-CRP was 1.08 mg/L (0.43-3.00 mg/L). The hs-CRP was significantly related to BMI (r=0.386, P <.001) but not to age and smoking habit. There were no significant relationships between basal hs-CRP and any of the measured IVF outcomes. Conclusions These findings demonstrate that serum hs-CRP concentration is not a predictive marker of cycle or pregnancy outcome in women undergoing IVF treatment.
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