期刊
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
卷 15, 期 6, 页码 624-630出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/10286020.2013.793181
关键词
Psoralea corylifolia; Fabaceae; cytotoxicity; isoflavonoids; corylifol D; corylifol E
资金
- Natural Science Foundation of Qinghai Province [2012-Z-904]
- Innovation Capacity Building in Guangxi Science and Technology Agency [10100027-3]
Bioassay directed isolation of the EtOAc extract from a traditional Chinese medicine Psoralea corylifolia resulted in the purification of two isoflavonoids, corylifols D (1) and E (2), along with four known ones. The structures of 1 and 2 were determined by extensive 1D and 2D NMR and MS data analyses. When tested against HepG2 and Hep3B hepatocellular carcinoma cell lines, corylifol A (4) displayed IC50 values of 4.6 and 13.5g/ml, respectively.
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