期刊
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
卷 13, 期 7, 页码 604-610出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/10286020.2011.578069
关键词
tectoridin; metabolism; glucuronidation; rat; urine
资金
- Research Fund for the Doctoral Program of Higher Education, China [200801630007]
- Science and Technology Department of Liaoning Province, China [20082260233]
Tectoridin is an active isoflavone from the rhizome of Belamcanda chinensis and flower of Pueraria thomsonii Benth, possessing an anti-inflammation action and the protective effect against ethanol-induced intoxication and hepatic injury. The metabolism of tectoridin was investigated in rats. Nine metabolites were isolated by using repeated chromatographic methods and identified by spectroscopic methods including UV, IR, mass spectrometry, and NMR experiments. A new compound was determined as tectorigenin-7-O-beta-D-glucuronide (M-1), together with eight known compounds identified as irisolidone-7-O-beta-D-glucuronide (M-2), tectorigenin-7-O-sulfate (M-3), tectorigenin-4'-O-sulfate (M-4), tectorigenin (M-5), irisolidone (M-6), isotectorigenin (M-7), genistein (M-8), and daidzein (M-9), respectively. The metabolic pathway of tectoridin was proposed, which is important to understand its metabolic fate and disposition in humans.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据