期刊
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
卷 13, 期 9, 页码 861-868出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/10286020.2011.599321
关键词
baicalein; flavones; metabolites; human plasma; LC-MS/MS; HPLC-DAD
资金
- National Natural Science Foundation of China [30225049]
The metabolites of baicalein in human plasma were investigated after taking baicalein, which is one of the main bioactive flavones in Scutellaria baicalensis Georgi. Five metabolites (M1-M5) together with the parent drug baicalein (P) were detected and identified by the HPLC-diode-array detector (DAD) and LC-MS/MS methods. Among them, 7-methoxybaicalein 6-O-glucuronide (M5) is a new metabolite. Based on the results, the proposed metabolic pathway of baicalein in humans was inferred.
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