期刊
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
卷 12, 期 9, 页码 793-800出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/10286020.2010.505187
关键词
Bufo bufo gargarizans; toad skin; cinobufotalin 3-nonanedioylarginine ester; bufotalin 3-pimeloylarginine ester; cytotoxicity
资金
- Natural Science Foundation of Fujian Province of China [2010J05087]
To study the chemical composition of the skin of Bufo bufo gargarizans, many kinds of chromatography methods were used in the isolation procedures, while the structures of isolated compounds were determined on the basis of their NMR and MS spectral analysis. As a result, two new compounds were isolated from its ethanolic extract and characterized as cinobufotalin 3-nonanedioylarginine ester (8) and bufotalin 3-pimeloylarginine ester (14). Furthermore, 13 known compounds were obtained. Isolated bufadienolides showed significant inhibition effect against SMMC-7721 cell lines in vitro.
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