4.4 Article

Chemical constituents of the stem bark of Morus cathayana

期刊

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
卷 12, 期 6, 页码 505-515

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TAYLOR & FRANCIS LTD
DOI: 10.1080/10286020.2010.489817

关键词

Morus cathayana; flavonoids; cytotoxic activities

资金

  1. National Natural Science Foundation of China [20432030]
  2. Basic Scientific Research Foundation of the Central Government of China [2006QN04]
  3. Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Peking Union Medical College, Ministry of Education

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Phytochemical investigation of the stem bark of Morus cathayana led to the isolation and identification of six new compounds, cathayanons F-J (1-5) and cathayanin A (6), and two known compounds, cathayanins B-C (7-8). Their structures were elucidated by spectroscopic methods. Compounds 1, 2, 3, 5, and 7 exhibited weak activities against five human cancer cell lines, with IC50 values ranging from 4.7 to 9.8g/ml.

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