期刊
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
卷 11, 期 4, 页码 332-338出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/10286020902727348
关键词
Clematis parviloba; triterpenoid saponins; cytotoxic activity; parvilobaside A
Sixteen triterpenoid saponins (1-16) were isolated from the stems of Clematis parviloba, including a new compound, parvilobaside A (1), which was established as 23-O-acetylhederagenin-3-O-beta-D-ribopyranosyl-(1 -> 3)-alpha-L-rhamnopyranosyl-(1 -> 2)-alpha-L-arabinopyranoside on the basis of various spectroscopic techniques and chemical evidences. Among the isolated compounds, clematoside S (2) and a-hederin (4) showed moderate cytotoxic activities against four human tumor cell lines (HCT-8, Bel-7402, BGC-823, and A-2780) with IC50 values in the range of 1.44-6.86 mu g/ml.
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