期刊
NATURE REVIEWS DRUG DISCOVERY
卷 15, 期 2, 页码 125-142出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrd.2015.2
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资金
- Swedish Medical Research Council
- Swedish Cancer Society
- Royal Swedish Academy of Sciences
- Swedish Diabetes Foundation
- Swedish Foundation for Strategic Research
- Novo Nordisk Foundation
- Ragnar Soderberg foundation
- Knut and Alice Wallenberg Foundation
- Ruth and Nils-Erik Stenbacks Foundation
- Foundations for Proteoglycan Research
- Marie Sklodowska-Curie Innovative Training Network InCeM (Integrated Component Cycling in Epithelial Cell Motility)
- Uppsala University
Regulation of vascular permeability, recruitment of leukocytes from blood to tissue and angiogenesis are all processes that occur at the level of the microvasculature during both physiological and pathological conditions. The interplay between microvascular cells and leukocytes during inflammation, together with the emerging roles of leukocytes in the modulation of the angiogenic process, make leukocyte-vascular interactions prime targets for therapeutics to potentially treat a wide range of diseases, including pathological and dysfunctional vessel growth, chronic inflammation and fibrosis. In this Review, we discuss how the different cell types that are present in and around microvessels interact, cooperate and instruct each other, and in this context we highlight drug targets as well as emerging druggable processes that can be exploited to restore tissue homeostasis.
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