期刊
JOURNAL OF ARTIFICIAL ORGANS
卷 13, 期 1, 页码 31-37出版社
SPRINGER TOKYO
DOI: 10.1007/s10047-010-0482-3
关键词
Alzheimer's disease; Amyloid beta; Extracorporeal circulation; Adsorbent; Blood purification
资金
- KAKENHI [20509008]
- Ministry of Education, Culture, Sports, Science and Technology of Japan
- Grants-in-Aid for Scientific Research [20509008] Funding Source: KAKEN
The accumulation of amyloid beta (A beta) protein in the brain reflects the cognitive impairment noted in Alzheimer's disease. Recent studies have shown that brain A beta disappeared and cognitive improvement occurred as a result of passive or active A beta immunization. Peripheral administration of nonimmunization substances, such as GM1 ganglioside, also reduced brain A beta. Therefore, we hypothesized that the rapid removal of A beta from the blood by an extracorporeal system may act as a peripheral A beta sink from the brain. In the present study, we investigated the A beta removal activity of medical materials as a first step toward the design of an A beta removal system. First, the removal activities of six materials were studied for A beta(1-40) and A beta(1-42) by batch analysis in albumin solution or in human plasma for 1-16 h. Two of the six materials reduced the A beta concentrations by 90-99% within 1 h. Next, the two effective materials, hexadecyl-alkylated cellulose particles (HDC) and charcoal, were analyzed in a continuous single-pass system with minicolumns. Both materials showed around 81-90% removal activity for more than 2 h, which corresponded to over 4 l of plasma treatment in humans. In a human extracorporeal system, HDC also removed both A beta(1-40) and A beta(1-42) from whole blood circulation. In conclusion, biomedical materials were found that could remove A beta(1-40) and A beta(1-42) effectively in an extracorporeal system. It is now conceivable that further studies can be undertaken to reduce A beta concentrations in the brain to improve cognitive function.
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