期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 59, 期 6, 页码 3630-3632出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.00171-15
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资金
- Swedish Society of Medicine [SLS 169241]
- Marianne and Marcus Wallenberg Foundation
- Swedish Heart and Lung Foundation (Oscar II Jubilee Foundation)
- Swedish Society of Antimicrobial Chemotherapy
- Research Council of Southeast Sweden (FORSS)
We investigated the activity of meropenem-clavulanic acid (MEM-CLA) against 68 Mycobacterium tuberculosis isolates. We included predominantly multi- and extensively drug-resistant tuberculosis (MDR/XDR-TB) isolates, since the activity of MEM-CLA for resistant isolates has previously not been studied extensively. Using Middlebrook 7H10 medium, all but four isolates showed an MIC distribution of 0.125 to 2 mg/liter for MEM-CLA, below the non-species-related breakpoint for MEM of 2 mg/liter defined by EUCAST. MEM-CLA is a potential treatment option for MDR/XDR-TB.
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