期刊
JOURNAL OF ARTHROPLASTY
卷 29, 期 6, 页码 1128-1132出版社
CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS
DOI: 10.1016/j.arth.2013.12.012
关键词
biofilm; pulse lavage; total knee arthroplasty; single stage irrigation debridement; periprosthetic joint infection
类别
资金
- Woodward Family Endowment in Biomedical Engineering
- Pellegrini Endowment
In acute periprosthetic infection, irrigation and debridement with component retention has a high failure rate in some studies. We hypothesize that pulse lavage irrigation is ineffective at removing biofilm from total knee arthroplasty (TKA) components. Staphylococcus aureus biofilm mass and location was directly visualized on arthroplasty materials with a photon collection camera and laser scanning confocal microscopy. There was a substantial reduction in biofilm signal intensity, but the reduction was less than a ten-fold decrease. This suggests that irrigation needs to be further improved for the removal of biofilm mass below the necessary bioburden level to prevent recurrence of acute infection in total knee arthroplasty. (C) 2014 Elsevier Inc. All rights reserved.
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