期刊
NATURE PHYSICS
卷 11, 期 12, 页码 1074-+出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/NPHYS3471
关键词
-
资金
- Alfred P. Sloan Foundation
- NSF [PHY11-25915, ACI-1341006]
- [NSF-CMMI-1334611]
- [NSF-DMR-1352184]
- Direct For Mathematical & Physical Scien
- Division Of Materials Research [1352184] Funding Source: National Science Foundation
- Div Of Civil, Mechanical, & Manufact Inn
- Directorate For Engineering [1334611] Funding Source: National Science Foundation
Cell migration is important in many biological processes, including embryonic development, cancer metastasis and wound healing. In these tissues, a cell's motion is often strongly constrained by its neighbours, leading to glassy dynamics. Although self-propelled particle models exhibit a density-driven glass transition, this does not explain liquid-to-solid transitions in confluent tissues, where there are no gaps between cells and therefore the density is constant. Here we demonstrate the existence of a new type of rigidity transition that occurs in the well-studied vertex model for confluent tissue monolayers at constant density. We find that the onset of rigidity is governed by a model parameter that encodes single-cell properties such as cell-cell adhesion and cortical tension, providing an explanation for liquid-to-solid transitions in confluent tissues and making testable predictions about how these transitions differ from those in particulate matter.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据