期刊
JOURNAL OF APPLIED TOXICOLOGY
卷 34, 期 11, 页码 1235-1246出版社
WILEY
DOI: 10.1002/jat.3066
关键词
carbon nanomaterials; graphene; embryo toxicity; Japanese medaka; cytotoxicity; sonication
类别
资金
- National Institutes of Health [1DP2OD007394-01]
- Wallace H. Coulter Foundation
The increased utilization of graphene nanoribbons (GNRs) for biomedical and material science applications necessitates the thorough evaluation of potential toxicity of these materials under both intentional and accidental exposure scenarios. We here investigated the effects of structural disruption of GNRs (induced by low-energy bath and high-energy probe sonication) to in vitro (human cell lines), and in vivo (Oryzias latipes embryo) biological systems. Our results demonstrate that low concentration (20 mu gml(-1)) suspensions of GNRs prepared by as little as 1min of probe sonication can cause significant decreases in the overall metabolic state of cells in vitro, and increased embryo/larval mortality in vivo, as compared to bath sonicated or unsonicated suspensions. Structural analysis indicates that probe sonication leads to disruption in GNR structure and production of smaller carbonaceous debris, which may be the cause of the toxicity observed. These results point out the importance of assessing post-production structural modifications for any application using nanomaterials. Copyright (c) 2014 John Wiley & Sons, Ltd.
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