期刊
JOURNAL OF APPLIED TOXICOLOGY
卷 34, 期 11, 页码 1188-1199出版社
WILEY
DOI: 10.1002/jat.3018
关键词
Cancer nanotechnology; Gambogic Acid; Graphene; Single-Walled Carbon Nanotubes; Nanodelivery; Breast cancer; Pancreatic cancer
类别
资金
- Department of Defense [X81XWH-11-1-0795]
- Arkansas Breast Cancer Research Program/University of Arkansas for Medical Sciences Translational Research Institute Clinical Translational Science Award [UL1TR000039]
Graphene and single-walled carbon nanotubes were used to deliver the natural low-toxicity drug gambogic acid (GA) to breast and pancreatic cancer cells in vitro, and the effectiveness of this complex in suppressing cellular integrity was assessed. Cytotoxicity was assessed by measuring lactate dehydrogenase release, mitochondria dehydrogenase activity, mitochondrial membrane depolarization, DNA fragmentation, intracellular lipid content, and membrane permeability/caspase activity. The nanomaterials showed no toxicity at the concentrations used, and the antiproliferative effects of GA were significantly enhanced by nanodelivery. The results suggest that these complexes inhibit human breast and pancreatic cancer cells grown in vitro. This analysis represents a first step toward assessing their effectiveness in more complex, targeted, nanodelivery systems. Copyright (c) 2014 John Wiley & Sons, Ltd.
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