期刊
NATURE NEUROSCIENCE
卷 18, 期 5, 页码 718-+出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.3974
关键词
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资金
- French National Agency for Research [ANR-2010-BLANC-1411, ANR-13-SAMA-0006-05, ANR-07-BSYS-010 VESTICODE, ANR-13-BSV4-0016]
- Fondation de Recherche Medicale
- European Union FP6 specific targeted project [LSHM-CT-2007-037765]
- UK Medical Research Council [MC_U1175975156]
- MRC [MC_U117597156] Funding Source: UKRI
- Medical Research Council [MC_U117597156] Funding Source: researchfish
- Wellcome Trust [096436/B/11/Z] Funding Source: researchfish
- Agence Nationale de la Recherche (ANR) [ANR-13-BSV4-0016, ANR-13-SAMA-0006] Funding Source: Agence Nationale de la Recherche (ANR)
The ability of the brain to rapidly process information from multiple pathways is critical for reliable execution of complex sensorymotor behaviors, yet the cellular mechanisms underlying a neuronal representation of multimodal stimuli are poorly understood. Here we explored the possibility that the physiological diversity of mossy fiber (MF) to granule cell (GC) synapses in the mouse vestibulocerebellum may contribute to the processing of coincident multisensory information at the level of individual GCs. We found that the strength and short-term dynamics of individual MF-GC synapses can act as biophysical signatures for primary vestibular, secondary vestibular and visual input pathways. Most GCs receive inputs from different modalities, which, when coactivated, produced enhanced GC firing rates and distinct first spike latencies. Thus, pathway-specific synaptic response properties permit temporal coding of correlated multisensory inputs by single GCs, thereby enriching sensory representation and facilitating pattern separation.
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