期刊
NATURE NEUROSCIENCE
卷 18, 期 11, 页码 1664-1671出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.4135
关键词
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资金
- 16 US National Institutes of Health (NIH) [1U54MH091657]
- McDonnell Center for Systems Neuroscience at Washington University
- NIH [EB009666, T32 DA022975]
- US National Science Foundation
Functional magnetic resonance imaging (fMRI) studies typically collapse data from many subjects, but brain functional organization varies between individuals. Here we establish that this individual variability is both robust and reliable, using data from the Human Connectome Project to demonstrate that functional connectivity profiles act as a 'fingerprint' that can accurately identify subjects from a large group. Identification was successful across scan sessions and even between task and rest conditions, indicating that an individual's connectivity profile is intrinsic, and can be used to distinguish that individual regardless of how the brain is engaged during imaging. Characteristic connectivity patterns were distributed throughout the brain, but the frontoparietal network emerged as most distinctive. Furthermore, we show that connectivity profiles predict levels of fluid intelligence: the same networks that were most discriminating of individuals were also most predictive of cognitive behavior. Results indicate the potential to draw inferences about single subjects on the basis of functional connectivity fMRI.
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