期刊
NATURE NEUROSCIENCE
卷 18, 期 3, 页码 373-375出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.3937
关键词
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资金
- US National Institutes of Health [R01 EY015815, T32 MH064931, F31 NS082213]
- US National Science Foundation [0909667]
- Vanderbilt University
To examine the interaction between molecular, electrical and behavioral circadian rhythms, we combined optogenetic manipulation of suprachiasmatic nucleus (SCN) firing rate with bioluminescence imaging and locomotor activity monitoring. Manipulating firing rate reset circadian rhythms both ex vivo and in vivo, and this resetting required spikes and network communication. This suggests that SCN firing rate is fundamental to circadian pacemaking as both an input to and output of the molecular clockworks.
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