期刊
NATURE NEUROSCIENCE
卷 18, 期 9, 页码 1230-+出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.4068
关键词
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资金
- US Public Health Service [DA03906, DA12513, DA015369]
- Neuroscience Institute, Medical University of South Carolina
It is widely accepted that D1 dopamine receptor-expressing striatal neurons convey their information directly to the output nuclei of the basal ganglia, whereas D2-expressing neurons do so indirectly via pallidal neurons. Combining optogenetics and electrophysiology, we found that this architecture does not apply to mouse nucleus accumbens projections to the ventral pallidum. Thus, current thinking attributing D1 and D2 selectivity to accumbens projections akin to dorsal striatal pathways needs to be reconsidered.
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