期刊
NATURE NEUROSCIENCE
卷 19, 期 1, 页码 111-+出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.4191
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资金
- US National Institute on Drug Abuse (NIDA)
- NATIONAL INSTITUTE ON DRUG ABUSE [ZIADA000587] Funding Source: NIH RePORTER
Correlative studies have strongly linked phasic changes in dopamine activity with reward prediction error signaling. But causal evidence that these brief changes in firing actually serve as error signals to drive associative learning is more tenuous. Although there is direct evidence that brief increases can substitute for positive prediction errors, there is no comparable evidence that similarly brief pauses can substitute for negative prediction errors. In the absence of such evidence, the effect of increases in firing could reflect novelty or salience, variables also correlated with dopamine activity. Here we provide evidence in support of the proposed linkage, showing in a modified Pavlovian over-expectation task that brief pauses in the firing of dopamine neurons in rat ventral tegmental area at the time of reward are sufficient to mimic the effects of endogenous negative prediction errors. These results support the proposal that brief changes in the firing of dopamine neurons serve as full-fledged bidirectional prediction error signals.
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