期刊
NATURE NEUROSCIENCE
卷 18, 期 8, 页码 1123-+出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.4056
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资金
- Boehringer Ingelheim Fonds PhD fellowship
- German Research Association (DFG) [LE 2250/5-1]
- Ellison Medical Foundation grant [AG-NS-0724-10]
- Walter F. Heiligenberg Professorship
- National Science Foundation Collaborative Research in Computational Neuroscience [1010463]
- US National Institutes of Health [R21 MH100354, R01 NS086947]
- Div Of Information & Intelligent Systems
- Direct For Computer & Info Scie & Enginr [1010463] Funding Source: National Science Foundation
The superficial layers of the medial entorhinal cortex (MEC) are a major input to the hippocampus. The high proportion of spatially modulated cells, including grid cells and border cells, in these layers suggests that MEC inputs are critical for the representation of space in the hippocampus. However, selective manipulations of the MEC do not completely abolish hippocampal spatial firing. To determine whether other hippocampal firing characteristics depend more critically on MEC inputs, we recorded from hippocampal CA1 cells in rats with MEC lesions. Theta phase precession was substantially disrupted, even during periods of stable spatial firing. Our findings indicate that MEC inputs to the hippocampus are required for the temporal organization of hippocampal firing patterns and suggest that cognitive functions that depend on precise neuronal sequences in the hippocampal theta cycle are particularly dependent on the MEC.
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