期刊
NATURE NANOTECHNOLOGY
卷 10, 期 2, 页码 176-182出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/NNANO.2014.282
关键词
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资金
- National Natural Sciences Foundation of China [21127901, 21321003, 21175139, 21305144, 21205123]
- Chinese Academy of Sciences
- The Ohio State University Start-up Funds
Label and label-free methods to image carbon-based nanomaterials exist. However, label-based approaches are limited by the risk of tag detachment over time, and label-free spectroscopic methods have slow imaging speeds, weak photoluminescence signals and strong backgrounds. Here, we present a label-free mass spectrometry imaging method to detect carbon nanotubes, graphene oxide and carbon nanodots in mice. The large molecular weights of nanoparticles are difficult to detect using conventional mass spectrometers, but our method overcomes this problem by using the intrinsic carbon cluster fingerprint signal of the nanomaterials. We mapped and quantified the sub-organ distribution of the nanomaterials in mice. Our results showed that most carbon nanotubes and nanodots were found in the outer parenchyma of the kidney, and all three materials were seen in the red pulp of the spleen. The highest concentrations of nanotubes in the spleen were found within the marginal zone.
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