期刊
NATURE METHODS
卷 12, 期 8, 页码 751-U86出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/NMETH.3455
关键词
-
资金
- US National Institutes of Health [1R01-GM106303]
- Protein Structure Initiative grant [U54-GM094597]
- NATIONAL CANCER INSTITUTE [P30CA008748] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [U54GM094597, R01GM106303] Funding Source: NIH RePORTER
Accurate determination of protein structure by NMR spectroscopy is challenging for larger proteins, for which experimental data are often incomplete and ambiguous. Evolutionary sequence information together with advances in maximum entropy statistical methods provide a rich complementary source of structural constraints. We have developed a hybrid approach (evolutionary coupling-NMR spectroscopy; ECEC-NMR) combining sparse NMR data with evolutionary residue-residue couplings and demonstrate accurate structure determination for several proteins 6-41 kDa in size.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据