期刊
NATURE METHODS
卷 12, 期 12, 页码 1132-+出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nmeth.3616
关键词
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资金
- National Institutes of Health [K25-EB015885, R21-EY023043, R01-EY025454, P41-EB015903, R33 CA174550]
- National Science Foundation [CBET-0853773]
- Human Frontier Science Program Young Investigator Grant [RGY0074/2013]
- Directorate For Engineering [1264356] Funding Source: National Science Foundation
- Div Of Chem, Bioeng, Env, & Transp Sys [1264356] Funding Source: National Science Foundation
Current measurements of the biomechanical properties of cells require physical contact with cells or lack subcellular resolution. Here we developed a label-free microscopy technique based on Brillouin light scattering that is capable of measuring an intracellular longitudinal modulus with optical resolution. The 3D Brillouin maps we obtained of cells in 2D and 3D microenvironments revealed mechanical changes due to cytoskeletal modulation and cell-volume regulation.
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