期刊
NATURE METHODS
卷 12, 期 10, 页码 969-974出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/NMETH.3536
关键词
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资金
- US National Institutes of Health (National Institute of Neurological Disorders and Stroke) [R01-NS080954]
- US National Science Foundation [ECCS-1351687]
- Stanford Bio-X NeuroVentures program
- Stanford Bio-X Interdisciplinary Initiatives Program
- Stanford Interdisciplinary Graduate Fellowship through the Bio-X program
- Div Of Electrical, Commun & Cyber Sys
- Directorate For Engineering [1351687] Funding Source: National Science Foundation
To enable sophisticated optogenetic manipulation of neural circuits throughout the nervous system with limited disruption of animal behavior, light-delivery systems beyond fiber optic tethering and large, head-mounted wireless receivers are desirable. We report the development of an easy-to-construct, implantable wireless optogenetic device. Our smallest version (20 mg, 10 mm(3)) is two orders of magnitude smaller than previously reported wireless optogenetic systems, allowing the entire device to be implanted subcutaneously. With a radio-frequency (RF) power source and controller, this implant produces sufficient light power for optogenetic stimulation with minimal tissue heating (<1 degrees C). We show how three adaptations of the implant allow for untethered optogenetic control throughout the nervous system (brain, spinal cord and peripheral nerve endings) of behaving mice. This technology opens the door for optogenetic experiments in which animals are able to behave naturally with optogenetic manipulation of both central and peripheral targets.
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