期刊
JOURNAL OF APPLIED POLYMER SCIENCE
卷 131, 期 14, 页码 -出版社
WILEY
DOI: 10.1002/APP.40606
关键词
biomaterials; drug-delivery systems; electrospinning; fibers; phospholipids
资金
- Japan Society for the Promotion of Science (JSPS KAKENHI) [23360294, 21226006, 24656395]
- Ministry of Education, Culture, Sports, Science and Technology (MEXT)
- Grants-in-Aid for Scientific Research [24560860, 23360294, 21226006, 24656395] Funding Source: KAKEN
Electrospun nanofibers of poly (2-methacryloyloxyethyl phosphorylcholine) (MPC) possessing excellent hemocompatibility were successfully fabricated first. These nanofibers were investigated as drug-delivery vehicles for suppressing the acute thrombogenicity of vascular grafts to lower the risk of coronary artery disease by improving the graft patency rate; the graft patency rate is the percentage of patients who do not have any blockage in a graft after a stent-graft treatment. We varied the MPC concentrations in ethanol from 1 to 10 wt % to fabricate electrospun MPC fibers. Scanning electron microscopy images revealed that when the MPC concentration was lower than 5 wt %, beads instead of fibers were formed. When the MPC concentration was increased (> 5 wt %), uniform fibers were produced with average fiber diameters of about 160 nm (5 wt %), 640 nm (7.5 wt %), and 1270 nm (10 wt %). In vitro drug-release tests showed that a higher amount of drugs was diffused from MPC fibers with small diameters; this indicated a faster drug-release rate for the thinner MPC fibers. Diameter-controlled MPC fibers could be used as a new vascular graft materials. (C) 2014 Wiley Periodicals, Inc.
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