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Zein-Based Micro- and Nano-Particles for Drug and Nutrient Delivery: A Review

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JOURNAL OF APPLIED POLYMER SCIENCE
卷 131, 期 16, 页码 -

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WILEY
DOI: 10.1002/app.40696

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biomedical applications; composites; drug delivery systems; nanostructured polymers; proteins

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Zein is the major storage protein from corn with strong hydrophobicity and unique solubility and has been considered as a versatile food biopolymer. Due to the special tertiary structures, zein can self-assemble to form micro- and nano-particles through liquid-liquid dispersion or solvent evaporation approaches. Zein-based delivery systems have been particularly investigated for hydrophobic drugs and nutrients. Recently, increasing attention has been drawn to fabricate zein-based advanced drug delivery systems for various applications. In this review, the molecular models of zein tertiary structure and possible mechanisms involved in zein self-assembly micro- and nano-particles are briefly introduced. Then, a state-of-the-art introduction and discussion are given in terms of preparation, characterization, and application of zein-based particles as delivery systems in the fields of food science, pharmaceutics, and biomedicine. (c) 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 40696.

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