期刊
JOURNAL OF APPLIED POLYMER SCIENCE
卷 131, 期 1, 页码 -出版社
WILEY
DOI: 10.1002/app.39720
关键词
drug delivery systems; morphology; stimuli-sensitive polymers; gels; swelling
资金
- Natural Sciences and Engineering Research Council of Canada (NSERC Canada)
- Sentinel-Bioactive Paper Network
- China Scholarship Council
Poly(vinyl alcohol)s (PVA) with high and low molecular weights were chemically modified by introducing acetaldehyde onto the polymer backbone to induce thermal-responsive properties. The influence of both molecular weight ((Mw) over bar) and acetalization degree on the lower critical solution temperature (LCST) of thermo-sensitive polymer was investigated. Moreover, a temperature responsive hydrogel was prepared by controlled cross-linking of acetalized poly(vinyl alcohol) (APVA) and glutaraldehyde. As a model drug, ciprofloxacin was introduced into the prepared thermal sensitive hydrogel to reveal the drug loading and release behaviors. The structure, thermo-sensitivity, swelling/deswelling kinetics, morphology, and drug loading/release behaviors were also investigated. The results indicated that the APVA polymer solution exhibited temperature responsivity, and APVA with high acetalization degree showed low LCST, whereas those with high (Mw) over bar PVAs showed high LCST. Meanwhile, morphology study was identical with the swelling/de-swelling behavior. The loading and release of ciprofloxacin were controllable. (C) 2013 Wiley Periodicals, Inc.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据