期刊
JOURNAL OF APPLIED POLYMER SCIENCE
卷 125, 期 -, 页码 E468-E476出版社
WILEY
DOI: 10.1002/app.36757
关键词
electrospinning; PLGA; PLA; controllable properties; degradation
资金
- Chinese Jiangsu Province Key Lab Foundation [KJS0817]
- Cooperative innovation in the trinity of enterprises, campuses and research institutes in Jiangsu Province, China [BY2010129]
In this research, the PLGA/PLA-blended nanofibers were successfully prepared by electrospinning. The macromicro structure, thermal stability, hydrophilicity, mechanical properties, and in vitro degradation of the electrospun PLGA/PLA nanofibrous scaffolds are characterized by means of SEM, FTIR, DSC, TG, contact angle, instron tensile tester, and degradation testing. The results showed that electrospun PLGA/PLA-blended nanofibrous scaffolds possessed nanofibrous and porous structures. The structural stability, crystallinity, wettability, and mechanical properties, especially the in vitro degradation rate, of the electrospun PLGA/PLA-blended nanofibrous scaffolds could be controlled by regulating the blended ratio of the poly(lactide-co-glycolide) (PLGA) and poly(lactide) (PLA). The results indicated that the electrospun PLGA/PLA-blended nanofibrous scaffolds could be considered as ideal candidates for tissue engineering scaffolds.(C) 2012 Wiley Periodicals, Inc. J Appl Polym Sci, 2012
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