期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 59, 期 12, 页码 7830-7832出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.01583-15
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资金
- Merck, Inc.
- Astellas, Inc.
- Pfizer
- Mylan, Inc.
- T2 Biosystems
- Astellas
- Cubist
- Theravance
- Medicines Company
- Novartis
- Merck
- ContraFect
- Drais
- iCo
- MethylGene
- Sigma Tau
- Trius
Triazole prophylaxis has become the norm in patients with hematological malignancies. Breakthrough infections caused by Mucorales during triazole prophylaxis remain a challenging problem. We found that preexposure of Rhizopus oryzae to antifungal triazoles (fluconazole, voriconazole, posaconazole, and itraconazole) did not modify the in vitro susceptibility of Rhizopus oryzae to posaconazole. In contrast, preexposure of Rhizopus to triazoles was associated with the enhanced in vitro susceptibility of R. oryzae to amphotericin B. Preexposure to posaconazole did not alter the virulence of R. oryzae in the fly model of mucormycosis.
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