期刊
JOURNAL OF APPLIED POLYMER SCIENCE
卷 126, 期 -, 页码 E408-E417出版社
WILEY
DOI: 10.1002/app.36928
关键词
chitosan; alginate; hydrogel; ss-lapachone; colonic delivery
资金
- International Foundation for Science [IFS F/ 4095-5]
- Organization for the Prohibition of Chemical Weapons-OPCW
Few researches are directed at drug delivery systems for beta-lapachone (beta-lap), a powerful anticancer agent but with limited pharmaceutical use. To overcome its limitations, we investigated controlled delivery systems of beta-lap in simulated gastric fluids in vitro from chitosan (CS) and alginate (AL) hydrogel beads with purpose for oral administration. The AL-CS hydrogel beads were formed by coacervation and were characterized by morphology, swelling ratio, and their physicochemical properties. The hydrogel beads, with sizes of roughly 1 mm, presented good stability, and low porosity. The in vitro drug release profile was in good agreement with kinetics profiles and the Fickian model indicating diffusion as the release mechanism, with low burst effect, especially in an acid medium and allowing a prolonged release of similar to 72 h (pH 1.2; k2 = 0.19 +/- 0.04) and (pH 7.4; k2 = 0.20 +/- 0.01). The beads were resistant to the acid medium and may be an alternative for beta-lap therapy of colorectal cancer. (c) 2012 Wiley Periodicals, Inc. J Appl Polym Sci, 2012
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据