期刊
NATURE MEDICINE
卷 21, 期 8, 页码 863-865出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nm.3891
关键词
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资金
- EU FP7 project DIABAT [HEALTH-F2-2011-278373]
- Netherlands Organization for Scientific Research (NWO) [TOP 91209037]
- NWO [917.14.358]
Cold exposure may be a potential therapy for diabetes by increasing brown adipose tissue (BAT) mass and activity. Here we report that 10 d of cold acclimation (14-15 degrees C) increased peripheral insulin sensitivity by similar to 43% in eight type 2 diabetes subjects. Basal skeletal muscle GLUT4 translocation markedly increased, without effects on insulin signaling or AMP-activated protein kinase (AMPK) activation and only a minor increase in BAT glucose uptake.
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