期刊
NATURE MEDICINE
卷 21, 期 9, 页码 979-988出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nm.3935
关键词
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资金
- Henry E. Singleton fellowship
- US National Institute of Mental Health [5R01MH097104]
- Poitras Center for Affective Disorders Research at the Massachusetts Institute of Technology (MIT)
- Stanley Center for Psychiatric Research at Broad Institute of MIT and Harvard
- Nancy Lurie Marks Family Foundation
- Simons Foundation Autism Research Initiative (SFARI)
- Simons Center for the Social Brain at MIT
Recent advances in identifying risk-associated genes have provided unprecedented opportunities for developing animal models for psychiatric disease research with the goal of attaining translational utility to ultimately develop novel treatments. However, at this early stage, successful translation has yet to be achieved. Here we review recent advances in modeling psychiatric disease, discuss the utility and limitations of animal models, and emphasize the importance of shifting from behavioral analysis to identifying neurophysiological abnormalities, which are likely to be more conserved across species and thus may increase translatability. Looking forward, we envision that preclinical research will align with clinical research to build a common framework of comparable neurobiological abnormalities and to help form subgroups of patients on the basis of similar pathophysiology. Experimental neuroscience can then use animal models to discover mechanisms underlying distinct abnormalities and develop strategies for effective treatments.
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