期刊
NATURE MEDICINE
卷 21, 期 10, 页码 1139-+出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nm.3932
关键词
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资金
- National Institute of Allergy and Infectious Diseases: US Public Health Service [AI41505]
- US Army Medical Research and Material Command [Y1-AI-2642-12]
- US National Institutes of Health (NIH) [2R37AI05465-10]
- Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. [W81XWH-07-2-0067]
- US Department of Defense [W81XWH-07-2-0067]
Given the variation in the HIV-1 viral load (VL) set point across subjects, as opposed to a fairly stable VL over time within an infected individual, it is important to identify the characteristics of the host and virus that affect VL set point. Although recently infected individuals with multiple phylogenetically linked HIV-1 founder variants represent a minority of HIV-1 infections, we found-in two different cohorts-that more diverse HIV-1 populations in early infection were associated with significantly higher VL 1 year after HIV-1 diagnosis.
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