期刊
NATURE IMMUNOLOGY
卷 16, 期 10, 页码 1044-+出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ni.3248
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资金
- American Cancer Society [RSG-11-161-01-MPC]
- National Institutes of Health [AI105351, AI112579, AI115149, AI119160, AI059621, AI098428, HL11074103]
- National Institutes of Health, the National Cancer Institute
- Center for Cancer Research
The cellular and molecular events that drive the early development of innate lymphoid cells (ILCs) remain poorly understood. We show that the transcription factor TCF-1 is required for the efficient generation of all known adult ILC subsets and their precursors. Using novel reporter mice, we identified a new subset of early ILC progenitors (EILPs) expressing high amounts of TCF-1. EILPs lacked efficient T and B lymphocyte potential but efficiently gave rise to NK cells and all known adult helper ILC lineages, indicating that they are the earliest ILC-committed progenitors identified so far. Our results suggest that upregulation of TCF-1 expression denotes the earliest stage of ILC fate specification. The discovery of EILPs provides a basis for deciphering additional signals that specify ILC fate.
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