期刊
NATURE IMMUNOLOGY
卷 16, 期 8, 页码 880-+出版社
NATURE PORTFOLIO
DOI: 10.1038/ni.3213
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资金
- DFG
- BMBF [SysINFLAME (TP3/4)]
- Israel Science Foundation [270/09]
- German Centre for Infection Research (DZIF)
- Deutsche Forschungsgemeinschaft [PA921/4-1, SFB621-Z]
Secretory immunoglobulin A (SIgA) shields the gut epithelium from luminal antigens and contributes to host-microbe symbiosis. However, how antibody responses are regulated to achieve sustained host-microbe interactions is unknown. We found that mice and humans exhibited longitudinal persistence of clonally related B cells in the IgA repertoire despite major changes in the microbiota during antibiotic treatment or infection. Memory B cells recirculated between inductive compartments and were clonally related to plasma cells in gut and mammary glands. Our findings suggest that continuous diversification of memory B cells constitutes a central process for establishing symbiotic host-microbe interactions and offer an explanation of how maternal antibodies are optimized throughout life to protect the newborn.
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