期刊
NATURE IMMUNOLOGY
卷 17, 期 2, 页码 150-158出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ni.3319
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资金
- Danish Medical Research Council [12-124330, 1331-00133B]
- Novo Nordisk Foundation
- Lundbeck Foundation [R34-3855]
- Aarhus University Research Foundation
- EU [1333-00090A]
- US National Institutes of Health [AI065309]
- Faculty of Health Sciences, AU
- Danish National Research Foundation [DNRF107]
- Excellence Programme for Interdisciplinary Research [CDO2016]
- German Research Foundation (DFG) [SFB 1054]
- European Research Council [322865]
- Lundbeck Foundation [R198-2015-171, R108-2012-10358] Funding Source: researchfish
- Novo Nordisk Fonden [NNF14OC0011875, NNF13OC0006211, NNF15OC0017118] Funding Source: researchfish
- European Research Council (ERC) [322865] Funding Source: European Research Council (ERC)
Mucosal surfaces are exposed to environmental substances and represent a major portal of entry for microorganisms. The innate immune system is responsible for early defense against infections and it is believed that the interferons (IFNs) constitute the first line of defense against viruses. Here we identify an innate antiviral pathway that works at epithelial surfaces before the IFNs. The pathway is activated independently of known innate sensors of viral infections through a mechanism dependent on viral O-linked glycans, which induce CXCR3 chemokines and stimulate antiviral activity in a manner dependent on neutrophils. This study therefore identifies a previously unknown layer of antiviral defense that exerts its action on epithelial surfaces before the classical IFN response is operative.
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