期刊
NATURE IMMUNOLOGY
卷 16, 期 9, 页码 927-932出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ni.3227
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资金
- National Institutes of Health [AI078526, AI096040, AI095985, AI069259, AI111595, AI112521, AI067031, AI118468]
- American Foundation for AIDS Research [108547-53-RGRL]
- Harvard Center for AIDS Research [AI060354]
- Ragon Institute of MGH, MIT and Harvard
Natural killer (NK) cells have traditionally been considered nonspecific components of innate immunity, but recent studies have shown features of antigen-specific memory in mouse NK cells. However, it has remained unclear whether this phenomenon also exists in primates. We found that splenic and hepatic NK cells from SHIVSF162p3-infected and SIVmac251-infected macaques specifically lysed Gag- and Env-pulsed dendritic cells in an NKG2-dependent fashion, in contrast to NK cells from uninfected macaques. Moreover, splenic and hepatic NK cells from Ad26-vaccinated macaques efficiently lysed antigen-matched but not antigen-mismatched targets 5 years after vaccination. These data demonstrate that robust, durable, antigen-specific NK cell memory can be induced in primates after both infection and vaccination, and this finding could be important for the development of vaccines against HIV-1 and other pathogens.
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