期刊
JOURNAL OF APPLIED PHYSIOLOGY
卷 116, 期 1, 页码 3-12出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/japplphysiol.01054.2013
关键词
chemosensitivity; collapsible airway; sleep apnea
资金
- National Heart, Lung, and Blood Institute [HL-099724, HL-15469]
- Veterans Administration Merit Review
We review evidence in support of significant contributions to the pathogenesis of obstructive sleep apnea (OSA) from pathophysiological factors beyond the well-accepted importance of airway anatomy. Emphasis is placed on contributions from neurochemical control of central respiratory motor output through its effects on output stability, upper airway dilator muscle activation, and arousability. In turn, we consider the evidence demonstrating effective treatment of OSA via approaches that address each of these pathophysiologic risk factors. Finally, a case is made for combining treatments aimed at both anatomical and ventilatory control system deficiencies and for individualizing treatment to address a patient's own specific risk factors.
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