期刊
JOURNAL OF APPLIED PHYSIOLOGY
卷 115, 期 9, 页码 1219-1226出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/japplphysiol.00885.2013
关键词
ischemia; blood pressure; blood flow; claudication; exercise
资金
- National Institutes of Health [P01 HL096570, UL1 TR000127, R01 HL098379]
Peripheral arterial disease (PAD) is an atherosclerotic condition that can provoke symptoms of leg pain (intermittent claudication) during exercise. Because PAD is often observed with comorbid conditions such hypertension, dyslipidemia, diabetes, cigarette smoking, and/or physical inactivity, the pathophysiology of PAD is certainly complex and involves multiple organ systems. Patients with PAD are at high risk for myocardial infarction, stroke, and all-cause mortality. For this reason, a better physiological understanding of the pathogenesis and treatment options for PAD patients is necessary and forms the basis of this Physiology in Medicine review.
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