期刊
JOURNAL OF APPLIED PHYSIOLOGY
卷 115, 期 5, 页码 688-696出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/japplphysiol.00491.2013
关键词
vagus; reflex; hyperthermia; extravasation; asthma
资金
- National Heart, Lung, and Blood Institute [HL-96914]
- US Department of Defense DMRDP/USAMRMC/TATRC [W81XWH-10-2-0189]
- ROC [NSC98-2917-I-038-101]
This study was carried out to determine the effect of allergic inflammation on the airway response to increasing airway temperature. Our results showed the following: 1) In Brown-Norway rats actively sensitized by ovalbumin (Ova), isocapnic hyperventilation with humidified warm air (HWA) for 2 min raised tracheal temperature (T-tr) from 33.4 +/- 0.6 degrees C to 40.6 +/- 0.1 degrees C, which induced an immediate and sustained (>10 min) increase in total pulmonary resistance (R-L) from 0.128 +/- 0.004 to 0.212 +/- 0.013 cmH(2)O.ml(-1).s (n = 6, P +/- 0.01). In sharp contrast, the HWA challenge caused the same increase in T-tr but did not generate any increase in R-L in control rats. 2) The increase in R-L in sensitized rats was reproducible when the same HWA challenge was repeated 60-90 min later. 3) This bronchoconstrictive effect was temperature dependent: a slightly smaller increase in peak T-tr (39.6 +/- 0.2 degrees C) generated a significant but smaller increase in R-L in sensitized rats. 4) The HWA-induced bronchoconstriction was not generated by the humidity delivered by the HWA challenge alone, because the same water content delivered by saline aerosol at room temperature had no effect. 5) The HWA-evoked increase in R-L in sensitized rats was not blocked by atropine but was completely prevented by pretreatment either with a combination of neurokinin (NK)-1 and NK-2 antagonists or with formoterol, a beta(2) agonist, before the HWA challenge. This study showed that increasing airway temperature evoked a pronounced and reversible increase in airway resistance in sensitized rats and that tachykinins released from the vagal bronchopulmonary C-fiber endings were primarily responsible.
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