期刊
JOURNAL OF APPLIED PHYSIOLOGY
卷 108, 期 5, 页码 1417-1424出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/japplphysiol.01261.2009
关键词
control of breathing; carbon dioxide; pH; systems physiology
资金
- National Institutes of Health [HL-28066, HD-36379]
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT [P01HD036379] Funding Source: NIH RePORTER
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R37HL028066, R01HL028066] Funding Source: NIH RePORTER
Nattie E, Li A. Central chemoreception in wakefulness and sleep: evidence for a distributed network and a role for orexin. J Appl Physiol 108: 1417-1424, 2010. First published February 4, 2010; doi:10.1152/japplphysiol.01261.2009.-This minireview examines data showing the locations of central chemoreceptor sites as identified by the presence of ventilatory responses to focal, mild acidification produced in unanesthetized animals in vivo, how the site-specific responses vary by arousal state, and what the emerging role of orexin might be in this state-dependent central chemoreceptor system. We comment on the organization of this distributed central chemoreceptor system and suggest that interactions among sites are synergistic and not additive, which is an important aspect of its normal function.
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