期刊
JOURNAL OF APPLIED PHYSIOLOGY
卷 109, 期 5, 页码 1538-1544出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/japplphysiol.00338.2010
关键词
temperature regulation; vascular; heat; cold; microvascular
资金
- NHLBI NIH HHS [R21 HL098645, R01 HL093238] Funding Source: Medline
- NIA NIH HHS [R01 AG007004] Funding Source: Medline
Holowatz LA, Kenney WL. Peripheral mechanisms of thermoregulatory control of skin blood flow in aged humans. J Appl Physiol 109: 1538-1544, 2010. First published April 22, 2010; doi: 10.1152/japplphysiol.00338.2010.-Human skin blood flow is controlled via dual innervation from the sympathetic nervous system. Reflex cutaneous vasoconstriction and vasodilation are both impaired with primary aging, rendering the aged more vulnerable to hypothermia and cardiovascular complications from heat-related illness. Age-related alterations in the thermoregulatory control of skin blood flow occur at multiple points along the efferent arm of the reflex, including 1) diminished sympathetic outflow, 2) altered presynaptic neurotransmitter synthesis, 3) reduced vascular responsiveness, and 4) impairments in downstream (endothelial and vascular smooth muscle) second-messenger signaling. This mechanistic review highlights some of the recent findings in the area of aging and the thermoregulatory control of skin blood flow.
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