期刊
JOURNAL OF APPLIED PHYSIOLOGY
卷 108, 期 3, 页码 584-588出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/japplphysiol.00873.2009
关键词
airway closure; breath
资金
- Swedish Heart-Lung Foundation
Almstrand A, Bake B, Ljungstrom E, Larsson P, Bredberg A, Mirgorodskaya E, Olin A. Effect of airway opening on production of exhaled particles. J Appl Physiol 108: 584-588, 2010. First published January 7, 2010; doi:10.1152/japplphysiol.00873.2009.-The technique of sampling exhaled air is attractive because it is noninvasive and so allows repeated sampling with ease and no risk for the patient. Knowledge of the biomarkers' origin is important to correctly understand and interpret the data. Endogenous particles, formed in the airways, are exhaled and reflect chemical composition of the respiratory tract lining fluid. However, the formation mechanisms and formation sites of these particles are unknown. We hypothesize that airway opening following airway closure causes production of airborne particles that are exhaled. The objective of this study was to examine production of exhaled particles following varying degrees of airway closure. Ten healthy volunteers performed three different breathing maneuvers in which the initial lung volume preceding an inspiration to total lung capacity was varied between functional residual capacity (FRC) and residual volume (RV). Exhaled particle number concentrations in the size interval 0.30-2.0 mu m were recorded. Number concentrations of exhaled particles showed a 2- to 18-fold increase after exhalations to RV compared with exhalations where no airway closure was shown [8,500 (810-28,000) vs. 1,300 (330-13,000) particles/expired liter, P = 0.012]. The difference was most noticeable for the smaller size range of particles (< 1 mu m). There were significant correlations between particle concentrations for the different maneuvers. Our results show that airway reopening following airway closure is an important mechanism for formation of endogenous exhaled particles and that these particles originate from the terminal bronchioles.
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