期刊
JOURNAL OF APPLIED PHYSIOLOGY
卷 107, 期 4, 页码 1328-1338出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/japplphysiol.00661.2009
关键词
blood pressure; vascular; obesity; Bmal1; diabetes
资金
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL089576, R01HL085827] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [K01DK070658] Funding Source: NIH RePORTER
Rudic RD, Fulton DJ. Pressed for time: the circadian clock and hypertension. J Appl Physiol 107: 1328-1338, 2009. First published August 13, 2009; doi:10.1152/japplphysiol.00661.2009.-Hypertension is a major risk factor for cardiovascular disease and death. The silent rise of blood pressure that occurs over time is largely asymptomatic. However, its impact is deafening-causing and exacerbating cardiovascular disease, end-organ damage, and death. The present article addresses recent observations from human and animal studies that provide new insights into how the circadian clock regulates blood pressure, contributes to hypertension, and ultimately evolves vascular disease. Further, the molecular components of the circadian clock and their relationship with locomotor activity, metabolic control, fluid balance, and vascular resistance are discussed with an emphasis on how these novel, circadian clock-controlled mechanisms contribute to hypertension.
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