期刊
JOURNAL OF APPLIED PHYSIOLOGY
卷 107, 期 4, 页码 1190-1194出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/japplphysiol.00282.2009
关键词
neuromuscular junction; electrophysiology
资金
- National Institutes of Health (NIH) [1-KO8-HD-052619, R24-HD-050838, 5-K25NS-41975, P01-NS-055976, NS-007440]
- Craig H. Neilsen Foundation
- Veteran Affairs Medical Research Service
Ollivier-Lanvin K, Lemay MA, Tessler A, Burns AS. Neuromuscular transmission failure and muscle fatigue in ankle muscles of the adult rat after spinal cord injury. J Appl Physiol 107: 1190-1194, 2009. First published July 30, 2009; doi:10.1152/japplphysiol.00282.2009.-Current evidence suggests that significant morphological changes occur in nerve-muscle connections caudal to spinal cord injury (SCI). To determine whether neuromuscular junction (NMJ) function is compromised after SCI, we investigated the contribution of NMJ failure to hindlimb muscle fatigue in control and spinalized adult rats. Repetitive supra-maximal nerve stimulation was applied to two muscle-nerve preparations: medial gastrocnemius (MG)-tibial and tibialis anterior (TA)-peroneal. NMJ transmission failure was evident in control and SCI animals after repetitive stimulation. At 2 wk post-SCI, NMJ transmission failure was greater in SCI animals compared with controls, but the difference was not significant (P = 0.205 for the MG and P = 0.053 for the TA). At 6 wk post-SCI, there was a significant but small difference in NMJ transmission failure for the TA between control and spinal animals. These results demonstrate that, although there may be a mild decrement in NMJ function, NMJ transmission remains largely intact for supramaximal nerve stimulation.
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