期刊
JOURNAL OF APPLIED PHYSIOLOGY
卷 104, 期 5, 页码 1304-1312出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/japplphysiol.01231.2007
关键词
exercise capacity; peak oxygen uptake; peroxisome proliferator-activated receptor gamma-coactivator-1 alpha
The induction of peroxisome proliferator-activated receptor-gamma coactivator-1 alpha (PGC-1 alpha), a key regulator of mitochondriogenesis, is well-established under multiple physical exercise regimens, including, endurance, resistance, and sprint training. We wanted to determine if increased expression of PGC-1 alpha in muscle is sufficient to improve performance during exercise in vivo. We demonstrate that muscle-specific expression of PGC-1 alpha improves the performance during voluntary as well as forced exercise challenges. Additionally, PGC-1 alpha transgenic mice exhibit an enhanced performance during a peak oxygen uptake exercise test, demonstrating an increased peak oxidative capacity, or whole body oxygen uptake. This increased ability to perform in multiple exercise paradigms is supported by enhanced mitochondrial function as suggested by increased mitochondrial gene expression, mitochondrial DNA, and mitochondrial enzyme activity. Thus this study demonstrates that upregulation of PGC-1 alpha in muscle in vivo is sufficient to greatly improve exercise performance under various exercise paradigms as well as increase peak oxygen uptake.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据