期刊
NATURE GENETICS
卷 47, 期 4, 页码 361-U195出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.3219
关键词
-
资金
- Ministerio de Ciencia e Innovacion (Spain) [BIO2011-30503-C02-01, PIM2010EPA-00606, CSD2009-00006]
- University of Glasgow
- Biotechnology and Biological Sciences Research Council (UK) [BB/I013873/1]
- Medical Research Council (UK)
- Ministerio de Ciencia e Innovacion, Spain [AGL2011-30170-CO2-02]
- Conselleria d'Educacio, Cultura i Esport, Generalitat Valenciana [GV2013-077]
- BBSRC [BBS/E/D/20310000, BBS/E/D/20231761, BB/I013873/1] Funding Source: UKRI
- MRC [MR/K001744/1, G0900740] Funding Source: UKRI
- NERC [NBAF010003] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BBS/E/D/20310000, BB/I013873/1, BBS/E/D/20231761] Funding Source: researchfish
- Medical Research Council [G0900740, MR/K001744/1] Funding Source: researchfish
- Natural Environment Research Council [NBAF010003] Funding Source: researchfish
The capacity of microbial pathogens to alter their host tropism leading to epidemics in distinct host species populations is a global public and veterinary health concern. To investigate the molecular basis of a bacterial host-switching event in a tractable host species, we traced the evolutionary trajectory of the common rabbit clone of Staphylococcus aureus. We report that it evolved through a likely human-to-rabbit host jump over 40 years ago and that only a single naturally occurring nucleotide mutation was required and sufficient to convert a human-specific S. aureus strain into one that could infect rabbits. Related mutations were identified at the same locus in other rabbit strains of distinct clonal origin, consistent with convergent evolution. This first report of a single mutation that was sufficient to alter the host tropism of a microorganism during its evolution highlights the capacity of some pathogens to readily expand into new host species populations.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据