期刊
NATURE GENETICS
卷 47, 期 7, 页码 727-+出版社
NATURE PORTFOLIO
DOI: 10.1038/ng.3306
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资金
- UK Medical Research Council [G0902043]
- European Molecular Biology Organization (EMBO)
- BBSRC [BB/E024211/1] Funding Source: UKRI
- MRC [G0902043] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/E024211/1, G19438/2] Funding Source: researchfish
- Medical Research Council [G0902043] Funding Source: researchfish
Crossover recombination reshuffles genes and prevents errors in segregation that lead to extra or missing chromosomes (aneuploidy) in human eggs, a major cause of pregnancy failure and congenital disorders. Here we generate genome-wide maps of crossovers and chromosome segregation patterns by recovering all three products of single female meioses. Genotyping >4 million informative SNPs from 23 complete meioses allowed us to map 2,032 maternal and 1,342 paternal crossovers and to infer the segregation patterns of 529 chromosome pairs. We uncover a new reverse chromosome segregation pattern in which both homologs separate their sister chromatids at meiosis I; detect selection for higher recombination rates in the female germ line by the elimination of aneuploid embryos; and report chromosomal drive against non-recombinant chromatids at meiosis II. Collectively, our findings show that recombination not only affects homolog segregation at meiosis I but also the fate of sister chromatids at meiosis II.
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