期刊
NATURE GENETICS
卷 47, 期 2, 页码 126-131出版社
NATURE PORTFOLIO
DOI: 10.1038/ng.3186
关键词
-
资金
- Canadian Institutes of Health Research
- US National Institutes of Health [R01GM078598, R01MH101244, GM100233, HG006399]
- US National Science Foundation [1032255]
- Division Of Behavioral and Cognitive Sci
- Direct For Social, Behav & Economic Scie [1032255] Funding Source: National Science Foundation
Non-African populations have experienced size reductions in the time since their split from West Africans, leading to the hypothesis that natural selection to remove weakly deleterious Mutations has been less effective in the history of non-Africans. To test this hypothesis, we measured the per-genome accumulation of nonsynonymous substitutions across diverse pairs of populations. We find no evidence for a higher load of deleterious mutations in non-Africans. However, we detect significant differences among more divergent populations, as archaic Denisovans have accumulated nonsynonymous mutations faster than either modern humans or Neanderthals. To reconcile these findings with patterns that have been interpreted as evidence of the less effective removal of deleterious mutations in non-Africans than in West Africans, we Use simulations to show that the observed patterns are not likely to reflect changes in the effectiveness of selection after the populations split but are instead likely to be driven by other population genetic factors.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据